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Eric Xu ORCID: orcid.org/0000-0002-6829-8144 1 Cell Research volume 30 , pages 11401142 (2020) Cite this article 10k Accesses 52 Citations 21 Altmetric Metrics details Subjects Dear Editor, The glucagon-like peptide-1 receptor (GLP-1R) belongs to class B G protein-coupled receptors (GPCRs)

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GLP-1R signaling in the brain exerts antidepressive effects by improving cognitive processes, promoting neuroprotection and neurotransmitter release Patients suffering from depression are characterized by impaired neuronal activity and synaptic plasticity dysfunction, resulting in volumetric changes in brain regions which regulate emotions or the stress response such as the hippocampus and the prefrontal cortex

It's plausible, but unproven